2045, city of Roveast, Nevada (US). Roveast is a modern metropolis haunted by the Wolves, nocturnal creatures with anthropomorphic traits. Wolves show up during the night and are hunted by the Vigilants, hunter-androids, whose purpose is to protect humans against these ferocious beasts. In all this, Isaac is a 25-year-old delivery boy who's looking for his place in the world. Every day that passes weighs more than the previous, and as tensions between humans and Wolves continue to rise, Isaac finds himself devoured by guilt. He might hold the key to solving this never-ending conflict, but the price may be too high.
High school girl Yui found a mysterious boy lying unconscious on the beach. This mysterious boy can't remember where he is from, only that his name is "Sid." After a confrontation with the locals, they discover that Sid is one of the human weaponry developed by the Japanese government, known as "Uncanny Brains." As the powers of the UB unfold before them, will Sid's arrival on this island spell doom for Yui and her friends? (Source: MangaHelpers)